The Maumee River is a river in northwestern Ohio and northeastern Indiana in the United States. It is formed at Fort Wayne, Indiana by the confluence of the St. Joseph and St. Marys rivers, and meanders northeastwardly for 137 miles (220 km) through an agricultural region of glacial moraines before flowing into the Maumee Bay of Lake Erie at the city of Toledo, Ohio. It was designated an Ohio State Scenic River on July 18, 1974.

The Maumee has the largest watershed of any Great Lakes river with 8,316 square miles (21,540 km2). Its watershed includes a portion of southern Michigan. In addition to its source tributaries the St. Joseph and St. Marys rivers, the Maumee's principal tributaries are the Auglaize River and the Tiffin River, which join it at Defiance from the south and north, respectively.

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