Bishop Creek is a large stream in Inyo County, California. It is the largest tributary of the Owens River, with runoff at an average rate of 69,000 acre-feet per year (2.7 m³/s).

Bishop Creek has three forks, North, Middle and South. All have their headwaters in the eastern Sierra Nevada, near the border with Fresno County. The forks all flow into lakes while still at high elevations. The North Fork flows into North Lake, the Middle Fork flows into Lake Sabrina and the South Fork flows into South Lake. The North and Middle forks combine and are damed at Intake II, a small lake. The creek then begins its decent to the valley where it receives the South Fork shortly thereafter. The creek continues roughly east, flowing past the city of Bishop before its confluence with the Owens River.

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