The Ohio River is the largest tributary, by volume, of the Mississippi River. It is approximately 981 miles (1,580 km) long and is located in the Eastern United States.

The Ohio River is formed by the confluence of the Allegheny and Monongahela rivers at Point State Park in Pittsburgh, Pennsylvania. From there, it flows northwest through Allegheny and Beaver counties, before making an abrupt turn to the south-southwest at the West Virginia—Ohio—Pennsylvania triple-state line (near East Liverpool, Ohio, Chester, West Virginia, and Midland, Pennsylvania). From there, it forms the border between West Virginia and Ohio, upstream of Wheeling, West Virginia.

The river then follows a roughly southwest and then west-northwest course until Cincinnati, before bending to a west-southwest course for most of its length. It flows along the borders of West Virginia, Ohio, Kentucky, Indiana and Illinois, until it joins the Mississippi River near the city of Cairo, Illinois.

The world record for the largest blue catfish 104 pounds (47.2 kilograms) taken in the line class was set on the Ohio River in 1999.

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