The South Umpqua River is a tributary of the Umpqua River, approximately 95 miles (153 km) long, in southwestern Oregon in the United States. It drains part of the Cascade Range east of Roseburg. The river passes through a remote canyon in its upper reaches then emerges in the populated South Umpqua Valley east of Canyonville, Oregon.

It rises in the high Cascades north of Fish Mountain, formed by the confluence of two short forks in eastern Douglas County approximately 20 miles (32 km) northwest of Crater Lake. It flows generally southwest through a remote canyon in the Umpqua National Forest to Tiller, then west past Milo and Days Creek. It emerges into the South Umpqua Valley at Canyonville, passing under Interstate 5 and flowing north along highway past Tri-City, Myrtle Creek, and Roseburg. It joins the North Umpqua from the south to form the Umpqua approximately 6 miles (10 km) northwest of Roseburg. It receives Cow Creek from the south approximately 5 miles (8 km) southwest of Tri-City.

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