The Muskingum River is a tributary of the Ohio River, approximately 111 miles (179 km) long, in southeastern Ohio in the United States. An important commercial route in the 19th century, it flows generally southward through the eastern hill country of Ohio. Via the Ohio, it is part of the Mississippi River watershed.

The Muskingum is formed at Coshocton in east-central Ohio by the confluence of the Walhonding and Tuscarawas rivers. It flows in a meandering course southward past Conesville, Trinway and Dresden to Zanesville, and then southeastward past South Zanesville, Philo, Malta, McConnelsville, Beverly, Lowell, Stockport and Devola. It joins the Ohio at Marietta.

Along its course the Muskingum collects Wills Creek near Conesville; Wakatomika Creek at Dresden; the Licking River at Zanesville; Moxahala Creek at South Zanesville; and Wolf Creek near Beverly.

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